( May 16, 1845, near Kharkiv, Ukraine – July 16, 1916, Paris)
Russian microbiologist, Nobel laureate, best remembered for his pioneering research into the immune system.
Some interesting facts:
-born in a village near Kharkov in the Russian Empire (now Kharkiv, Ukraine)
-His first wife, Ludmila Feodorovovna, suffered from tuberculosis, of which she died in 1873. Her death, combined with other problems, caused Mechnikov to unsuccessfully attempt suicide, taking a large dose of opium. He married again in 1875, and his second wife, Olga, caught typhoid in 1880, causing Mechnikov to again attempt suicide—this time by injecting himself with relapsing fever, which didn't kill him, but made him very ill.
-He became interested in the study of microbes, and especially the immune system. In 1882 he resigned his position at Odessa University and set up a private laboratory at Messina to study comparative embryology, where he discovered phagocytosis after experimenting on the larvae of starfish. His theories were radical: certain white blood cells could engulf and destroy harmful bodies such as bacteria. The ‘sophisticated’ microbe hunters in the West — Pasteur, Behring, etc. — scorned the Russian and his humble theory.
-Mechnikov also developed a theory that aging is caused by toxic bacteria in the gut and that lactic acid could prolong life. Based on his theory, he drank sour milk every day. He died in 1916 at 71 years of age (well above the average life expectancy at the time).
-It was the last of these works, along with Metchnikoff's studies into the potential life-lengthening properties of lactic acid bacteria (LAB) that inspired Japanese scientist Minoru Shirota to begin investigating the causal relationship between bacteria and good intestinal health. Convinced that a healthy balance of intestinal bacteria held the key to man's general well-being, Shirota dedicated his life and work to isolating a strain of LAB which would pass into the intestines, positively contributing to the balance of gut flora. In 1935, he succeeded in cultivating a unique bacterium, sufficiently robust to bypass the acidic environment of the stomach and enter the intestines directly. He placed this pioneering strain into a fermented milk drink in order to make its benefits accessible to all - this drink remains available worldwide today (in a recipe almost unchanged from Shirota's original formula) as the Yakult drink.
Source: Wikipedia
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